Introduction of Investigator-initiated trial (IIT) & Common Issues 1. Aims of clinical trials: interests of an Investigator in a Clinical Trial 2. Classification of clinical trials (1) Industry-sponsored trial (IST) (2) Investigator-initiated trial (IIT) (3) Comparison between IST and IIT (4) Relation Between Industry Sponsorship and Study Outcome in Original Research Studies. 3. IIT experience sharing (1) Establish a Good Research Team (Friends) (2) Conduction of IIT (3) Ethical Considerations (4) Comment about IIT (5) General Responsibilities of an Investigator in IIT 4. Issues associated with IIT (1) Design and conduct (2) IRB issues (3) Common mistakes